Program

Plenary Lectures

[Program]

■Plenary Lecture 1

From analysis of the Hayabusa samples to Hayabusa2: Noble gas isotope mass spectrometry
Keisuke Nagao (Korea Polar Research Institute)

■Plenary Lecture 2

Translation of "Gas Biology" to medicine through advanced mass spectrometry
Makoto Suematsu (Keio University School of Medicine)

Award Lectures

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Day 2 Thursday, May 18 [Program]

Oral Sessions

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Day 1 Wednesday, May 17 [Program]

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Day 2 Thursday, May 18 [Program]

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Day 3 Friday, May 19 [Program]

■Session No

1B-O1

■Title

Clinical and societal implementation of mass spectrometry in Japan ―Challenges and Promises―

■Organizers

Fumio Nomura (Chiba Univ. Hospital) / Masayuki Kubota (ThermoFisher Scientific)

■Keynote

Fumio Nomura (Chiba Univ. Hospital),

■Scope

Mass spectrometry (MS) has undergone rapid technical development and its clinical applications are growing. Tandem mass spectrometry for newborn screening is now available nationwide in Japan. Bacterial identification using MALDI-TOF MS has now been widely used in the real world medicine, making a revolutionary shift in clinical diagnostic microbiology. MS offers analytical specificity far superior to that of immunoassays. MS applications in clinical chemistry laboratories, however, are still very limited. For its widespread adoption in clinical use, more simple pretreatment procedures, quality assurance and assay standardization and the automated operations are required. In this session, we are going to share “challenges and promises” in clinical and societal implementation of MS.

■Keywords

clinical microbiology, clinical chemistry, societal implementation, reference material

■Session No

1C-O1

■Title

Mass spectrometry for material development

■Organizers

Takahiro Hoshi (Nipponkayaku) / Kanae Teramoto (Shimadzu)

■Scope

Material manufacturers develop their own material, and they make value-add products by compounding and processing their materials. Analysis technology is an important issue to advance the development of these materials. In particular, mass spectrometry provides a great impact on the characterization because the precise molecular weight information of the analyte will be available by the measurement. However, due to the increased complexity of the real sample, the development in the analytical method for mass spectrometry has become an important aspect of the analysis for the implementation in the material development. In this session, we will discuss pre-processing, separation, ionization, data analysis and new analytical method of functional materials. Additionally we would like to discuss the future prospects of this field together with participants.

■Keywords

Polymer, Functional material, Analytical method development

■Session No

1D-O1

■Title

Recent advance of informatics and database sciences in metabolomics

■Organizer

Hiroshi Tsugawa (RIKEN CSRS) / Hiroyuki Yamamoto (HMT)

■Keynote

Masanori Arita (National Institute of Genetics)

■Scope

Informatics and database researches are essential in mass spectrometry (MS) based metablomics for the comprehensive identification of small biomolecules. This section will be an opportunity to discuss the recent advance of 1) raw MS data handling including peak picking, alignment, and missing value interpolation, 2) small molecule identification for unknown electron ionization- or tandem mass spectra, 3) MassBank database, and 4) data interpretation by multivariate analysis. On the other hand, the development of user friendly graphical user interface (viewer) should be a part of informatics science to eliminate the boundaries between biologists and informaticians. Metabolomics is an integrated research field of biology, analytical chemistry, and informatics, and here would be the place for sharing your opinions to improve metabolomics platforms.

■Keywords

metabolomics, identification, data processing, database

■Session No

1C-O2

■Title

Novel Developments in Earth and Planetary Sciences Based on Mass Spectrometry

■Organizers

Teruyuki Maruoka (University of Tsukuba), Hirochika Sumino (University of Tokyo)

■Keynote

Takeshi Ohno (Gakushuin University)

■Scope

Mass spectrometry has been one of the most essential techniques for Earth and Planetary Sciences. Although geoscientists in the 19th century discussed only major components in the target materials, they could discuss minor components and isotopic compositions after introducing mass spectrometry as a research tool. This lead not only to the increase in the number of analytical data, but also to the improvement of data quality. The techniques based on mass spectrometry, such as paleoenvironmental analysis of light stable isotopes, radiometric dating, and rare earth elements patterns, brought a revolution to Earth and Planetary Sciences. Besides the examples stated above, the introduction of novel mass spectrometry has produced novel developments for researchers. In this session, we would like to discuss the novel mass spectrometry techniques that will advance the research field in Earth and Planetary Sciences.

■Keywords

Isotopes, Trace elements, Trace species, Environmental Science

■Session No

1D-O2

■Title

Sampling, Desorption, Ionization and Ion Physics

■Organizers

Lee Chuin Chen (University of Yamanashi) / Satoshi Ninomiya (University of Yamanashi)

■Scope

The processes of making gaseous ions are of paramount importance for mass spectrometry. Before obtaining the ion that is mass (m/z) analyzable in the high vacuum, the processes of sample introduction (sampling), evaporation, desorption, gaseous ionization (EI,CI,APCI, Penning etc), ion desorption (from charged droplets), ion desolvation and ion introduction into the vacuum and the subsequent ion transmission have to be properly implemented. This session covers all topics related to these processes. Besides discussion on the fundamentals, ion physics, new methods, and hardware optimization, new proposals and the sharing of valuable experimental experience are also welcome.

■Keywords

Sampling, desorption, ionization, ion physics, ion transmission, ambient MS.

■Session No

2B-O1

■Title

Developing metabolomics: Teaching a new dog old tricks

■Organizers

Fumio Matsuda (Osaka Univ.) / Yoshihiro Izumi (Kyusyu Univ.)

■Keynote

Takaaki Nishioka (Kyoto Univ.)

■Scope

Metabolomics has been widely applied to a wide variety of fields such as medicine, food, agriculture, and environment with advancement of mass spectrometric techniques. However, even if the state-of-the-art measurement techniques are used, it has not reached an essential solution to the problems of metabolomics, such as identification and quantification of metabolites. This may be due to the fact that young researchers are dissatisfying basic knowledge on analytical chemistry.
In this session, we want to discuss about traditional knowledge and technologies of bioanalytical chemistry (e.g., chromatography, ionization, detection, understanding of mass spectral interpretation, and so on) for the further advances in metabolomics.

■Keywords

Metabolomics, Mass spectrometry, Metabolite identification, Quantitative analysis of metabolites

■Session No

2C-O1

■Title

Frontiers of protein and proteomics studies leading by mass spectrometry

■Organizers

Yoshio Kodera (Kitasato Univ.) / Tomoya Kinumi (AIST)

■Keynote

Masaki Matsumoto (Kyushu Univ.)

■Scope

The distinguishing characteristic of organism is their robustness underpinned by the diversity in molecular, cellular, individual organism levels. It is important to comprehend the molecular diversity for understanding the biological phenomena.  Developments in mass spectrometry enable us the comprehensive characterization of protein in terms of quantification, post-translational modification, isoform, as well as the protein analyses in single cell and protein complex.  The aim of this session is to discuss the current and future direction of mass spectrometry toward to understand biological function based on the protein analysis and proteomics.

■Keywords

protein, proteomics, post-translational modification, quantitative analysis, heterogeneity

■Session No

2D-O1

■Title

The front line of hardware developments for mass spectrometry

■Organizers

Daiki Asakawa (AIST) / Nobuyuki Zen (AIST)

■Keynote

Takashi Baba (SCIEX)

■Scope

MS is one of the most widely spreading technologies over multidisciplinary fields and its success lies with developments of novel hardware such as ion traps, dissociation systems, ion mobility spectrometers, detectors, and so on. Recently, however, the progress of instruments seems to be slow down and we strongly feel the importance of re-acceleration for their developments. In this session, we call for the presentations of the state-of-the-art MS hardware technologies and we would like to provide you the opportunity to get the future image of MS.

■Keywords

hardware development, new device, new hybrid design, dissociation system, ion mobility, detector

■Session No

3B-O1

■Title

Imaging Mass spectrometry, new fundamental techniques and applications

■Organizers

Yuki Sugiura (Keio Univ.) / Shuichi Shimma (Osaka Univ.)

■Keynote

Per Andren (Uppsala Univ.)

■Scope

Imaging mass spectrometry (IMS) has been received a significant amount of attention not only in the mass spectrometric community, but also in biological/medical societies. So far, numerous feasibility studies using IMS in drug and endogenous biomolecular imaging, as well as in clinical diagnosis has been reported. To not make this just a technological hype, we consider that insights from newcomers through discussions of new IMS fundamentals and applications, are necessary. Thus, the keywords of this session are new “applications”, “sample preparation methods” and “fusion with other imaging techniques”.

■Keywords

Molecular imaging, imaging mass spectrometry, new sample preparation

■Session No

3C-O1

■Title

Recent research of screening for bioactive substances using mass spectrometry

■Organizers

Ryuichi Sawa (Inst. of Microbial Chemistry) / Yasuhiko Bando (Biosys Technologies)

■Keynote

Satoru Nagatoishi (University of Tokyo)

■Scope

Screening for bioactive substances including natural products as lead compounds for pharmaceuticals and agricultural chemicals have been studied in a variety of the methods for many years. Due to the development of small compounds, the new lead discovery from natural products have become very difficult.
In recent years, the development of protein-protein interaction inhibitor (PPI Inhibitor) at intercellular systems instead of a conventional protein inhibitor gains popularity in the next generation drug discovery. The middle-size molecules such as bioactive natural products and peptides or FBDD (Fragment based drug discovery) has been attracting attention again.
In this session, we recruit the topics of the latest research for screening the bioactive compounds using a new method with mass spectrometry and expect to discuss for the development of this field of research.

■Keywords

PPI Inhibitor, bioactive component, middle-size molecules, natural product

■Session No

3D-O1

■Title

Ion mobility mass spectrometry and ion-molecule reactions

■Organizers

Shinji Nonose (Yokohama City Univ.) / Fuminori Misaizu (Tohoku Univ.)

■Keynote

Hajime Tanuma (Tokyo Metropolitan Univ.)

■Scope

Ion mobility mass spectrometry (IMS) and ion-molecule reactions provide a broad feature not only for practical applications but also in fundamental studies of gas-phase ion chemistry. In particular, IMS is now an important tool in structural biology for mass analysis of protein complexes. This session will focus on practical and fundamental aspects of IMS and ion-molecule reactions.

■Keywords

Ion mobility, ion-molecule reaction, structural biology using mass spectrometry

■Session No

3B-O2

■Title

Structural characterization and bioanalytical assay of biopharmaceuticals by mass spectrometry

■Organizers

Susumu Uchiyama (Osaka University), Ryoya Goda (Daiichi-Sankyo, Inc.)

■Keynote

Hyun Joo An (Chungnam National Univ.)

■Scope

Mass spectrometry is now essential method for the biophysical characterization and bioanalysis of biopharmaceuticals. In this session, we will discuss on the conventional but effective feature of mass spectrometry for the biophysical characterization, especially for the primary and higher order structures analyses, of biopharmaceuticals. Whereas, bioanalysis of drugs in complex biological samples is necessary for the evaluation of drugs’ safety and efficacy thus highly reliable method is required. Bioanalysis by mass spectrometry enables us to obtain valuable information that is hardly acquired by ligand binding assays. Current status, scope and existing problems of bioanalysis by mass spectrometry are discussed.

■Keywords

biopharmaceuticals, antibody, mass spectrometry, structure, bioassay

■Session No

3C-O2

■Title

Structural characterization of gaseous organic ions: Chemistry and applications

■Organizers

Takemichi Nakamura (RIKEN CSRS) / Masahiro Miyashita (Kyoto Univ.)

■Scope

Structural characterization of gaseous organic ions lies at the bottom of mass spectrometry applications in many fields, e.g., chemistry, medical and pharmaceutical science, omics life sciences, environmental sciences, etc. This session covers various aspects related to qualitative organic mass spectrometry, which includes structural characterization and identification of organic molecules, differentiation of isomers, etc. We welcome topics from experimental and theoretical studies, fundamentals and methodologies to applications related to chemistry and characterization of gaseous organic ions, which include (but not limited to) fragmentation of even and odd electron ions, various reactions of gaseous ions that involve bond cleavages and/or rearrangements, collision cross-section measurement and calculation, computational chemistry and spectroscopy, etc.

■Keywords

gas-phase ion chemistry, ion structure, fragmentation, collision cross-section, computational chemistry

■Session No

3D-O2

■Title

Exposome: Exposure analysis of chemical substances by biomonitoring or quantitative analysis of biological samples

■Organizers

Shoji F. Nakayama (National Institute for Environmental Studies) / Tomohiko Isobe (National Institute for Environmental Studies)

■Scope

The recent advance in omics technique has promoted the use of mass spectrometry in the life science field. Examples include metabolomics, proteomics and lipidomics for medical diagnosis. It is known however that interactions with the environment from the prenatal period onwards, or ‘exposome’, determines one’s health. There are many environmental factors that can affect human health. Mass spectrometry is one of the most potential technologies for the biomarker measurement of chemical exposures. It is important to develop low cost and high-throughput as well as high quality measurement technologies for quantitative chemical exposure analysis. This session will focus on state-of-the-art research on the quantitative biomonitoring technique and discuss about challenges and the future of the field.

■Keywords

Quantitative analysis of biological samples, biomonitoring, exposure analysis of chemical substances, high-throughput, quality assurance/quality control

Poster Presentations

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Day 1 Wednesday, May 17 [Program]

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Day 2 Thursday, May 18 [Program]

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Day 3 Friday, May 19 [Program]

Workshop

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Day 2 Thursday, May 18 [Program]

Workshop Overview

■Workshop No

1B-W1

■Title

Fundamental and practical aspects of LC/MS; Mass separation mechanism and MS/MS analysis

■Organizers

Hiroyuki Fukuda (Agilent Technologies) / Yoshihiko Takinami (Bruker Daltonics)

■Scope

MSSJ Corporate Program Working Group (MSSJ CPWG) is organizing a consortium of instrument manufacturers. One of the objectives of this effort is to bridge the society and a wide range of MS users and encourage people to attend the annual conferences and join the society. To pursue this end, CPWG plans to hold serial workshops that would be attended by many ordinary MS users to share common problems and exchange information. In this year's workshop, we focus on mass separation mechanism and MS/MS analysis.

■Keywords

MS as routine analytical tool, LC/MS, Mass separation mechanism, MS/MS analysis, MSSJ CPWG

Timetable

Timetable（PDF）
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