Speaker:
Professor Richard B. Cole (University of NewOrleans)
Time:
Wed., Aug. 18, 3 - 4 p.m.
Place:
Nishina Hall on the campus of RIKEN 2-1, Hirosawa, Wako, Saitama, 351-0198
Title:
An ElectrochemicalDevice and Anion Attachment for Improving Signals in Electrospray IonizationMass Spectrometry


Abstract: This seminar will outline approaches to creating ionic forms of compounds that do not offer high signal responses by conventional ESI-MS. This has been accomplished through two primary avenues. The first is the development of an electrochemistry / electrospray mass spectrometry (EC/ES-MS) device where the three-electrode electrochemical cell is placed directly inside the ES probe. This device promotes electrochemical reactions immediately prior to release of the solution into the mass spectrometer. No other EC/ES-MS system offers the potential to observe species of shorter lifetimes. The device allows the creation of radical cations (or anions) through one-electron oxidations (or reductions) of compounds that lack nucleophilic sites or acidic protons. The second development is the use of anion attachment as a means of ionizing compounds of low acidities in negative ion ESI-MS.


Professor Cole is one of the most distinguished scientists on fundamentals of electrospray ionization mass spectrometry (ESI-MS).

Reference:
Yoko Ohashi: tel: 048-467-9621 or 048-462-1111 ex. 6513
fax: 048-462-4699
Sadamu Kurono: tel: 048-467-9622 or 048-462-1111 ex. 6514

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