ࡱ > 2 4 1 9 R bjbj 2* l D > V | E G G G G G G $ $ D k ] k E E 9 9 J ٧s S F 9 9 0 9 9 M A L D I - T O F 00000000000k00000000000^n0000000xX N L B0 Q0 0 *'Y#ux0'Y]0*'Y;SqQT0*'YWy] 0% e q \ o \ a c ( \ s \ u p 1 1 ( _0j0K0_0K0n00) , 0u-Nؚ }) 0 e q \ o \ a c ( \ s \ u p 1 1 ( o00`0~0j0v0) , S0uf[) 0 e q \ o \ a c ( \ s \ u p 1 1 ( j0K0n0K0Z00F0) , -NΑTΐ) 0 e q \ o \ a c ( \ s \ u p 1 1 ( _0K0D00W0J0) , ؚN V7u) 0 e q \ o \ a c ( \ s \ u p 1 1 ( O00`0) , Ҟ0u) E Q \ * j c 2 \ * " F o n t : 00000000- +," \ * h p s 1 2 \ o \ a d ( \ s \ u p 1 1 ( ~0U0) , ck) 0 0 e q \ o \ a c ( \ s \ u p 1 1 ( J0) , 7u) 0 e q \ o \ a c ( \ s \ u p 1 1 ( B00K0000F0D0a0) , R] N) 0 e q \ o \ a c ( \ s \ u p 1 1 ( r00[0Q0D0X0) , ^,plel) 0 e q \ o \ a c ( \ s \ u p 1 1 ( j0H000S0F0D0a00F0) , ׂQgim Nΐ) ( eL T) N L B0 Q0 0 C h i r a l A m i n o A c i d R e c o g n i t i o n o f C r o w n E t h e r s b y M A L D I - T O F M a s s S p e c t r o m e t r y ( e@b^\0l T) N L B0 Q0 0 ( I S I R , O s a k a U n i v . 1 , K a n s a i U n i v . 2 , D e p t . o f M e d i c i n e , O s a k a U n i v . 3 , D e p t . o f E n g i n e e r i n g S c i e n c e , O s a k a U n i v . 4 ) %T . T a n a k a 1 , M . H a r a d a 2 , K . N a k a n o 3 , Y . T a k a i 1 , M . K u r o d a 3 , R . A r a k a w a 2 , K . H i r o s e 4 , K . N a e m u r a 4 ( ei) 1 0 0 ^2 0 0 w o r d z^ N L B0 Q0 0 C h i r a l a m i n o a c i d r e c o g n i t i o n o f c r o w n e t h e r s h a s b e e n i n v e s t i g a t e d u s i n g M A L D I - T O F m a s s s p e c t r o m e t r y c o u p l e d w i t h t h e e n a n t i o m e r l a b e l e d g u e s t m e t h o d . T h e p e a k i n t e n s i t y r a t i o ( I R I S v a l u e ) o f t h e d i a s t e r e o m e r i c h o s t - g u e s t c o m p l e x i o n s w a s c h o s e n a s a " " " " " " " " " " " " " " " " " " " " " " " " " " " " " " " " " " " " " " " " " " " " " " " " " " ( ,g 0e) Teg0 N L B0 Q0 0 01 . 00000000000h0000000x0000000iXxiXh0n00000000D}T[000000[ah0W00000n00000000n0 Ne0TMOSOjXY00KblE L - 000l 0(uD0f00F A B M S ( N B A m a t r i x ) 1 ) 00E S I M S ( M e O H ) 2 ) g00000RP[X3 ) 0ŏK0d0[ϑvk0UOg0M00S0h001XJTW0f0M0_00NVo0T000000000000M A L D I - T O F 00000000000k0b5_W0f0000XiQn0yr_0iW00F A B M S 0E S I M S h0n0k0Lc0_00 02 . ( a ) 000000k0C H C A , M S A {0K0D0O0d0K0n0-NK00D H B A 0xs0QW00( b ) [ 000] [ ( R ) 000] : [ ( S ) 000000 d 3 ] : [ 000000] 1 : 5 : 5 : 1 0 0 n0mTkM e O H / C H C l 3 1 1 nmk000teo^agN0[ 000000] 0 . 1 M 0xQW00( c ) 0 . 3 L 0\(u0000k0WX^06q~NqW00( d ) V o y a g e r R P ňnD E g0,n[W00( e ) I R I S $P0007_^k 0zl[W0_00e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e e 1 ) J . S . B r o d b e l t , M a s s S p e c t r o m . R e v . , 1 9 9 7 , 1 6 , 9 1 - 1 1 0 . 2 ) Y . T a k a i e t a l . , J . C h e m . S o c . , P e r k i n T r a n s . 2 , 1 9 9 8 , 7 0 1 - 7 1 0 . ( 00000) N L B0 Q0 0 M A L D I " C h i r a l R e c o g n i t i o n " C h i r a l C r o w n E t h e r " A m i n o A c i d " T O F M a s s Spectrometry T V Z \ ^ ` b d f h l n p x z & * 0 2 4 6 8 : ` n r z | ~ ŻŻŻŻŰ榝氻Ű榝氻Ű榝氻Ű榝氻ŰCJ OJ PJ QJ CJ OJ PJ QJ o(j OJ PJ QJ UH*OJ PJ QJ o( OJ PJ QJ o(OJ PJ o(5B*PJ ph 5B*PJ o(ph OJ PJ QJ CJ OJ PJ QJ o(CJ OJ PJ QJ > V n n z , j @ X F r b dh $ b dh ` a$ dh $a$ /^/` ^ , < > B v z ~ 8 D H P R T V X Z 5B*OJ PJ o(ph 5OJ PJ QJ 5B*OJ PJ QJ o(ph 5B*OJ PJ QJ ph H*OJ PJ QJ o( j OJ PJ QJ UOJ PJ QJ o(CJ OJ PJ QJ CJ OJ PJ QJ o(OJ PJ QJ ; n p ~ t v z | ( , . 6 > @ N R V X ӽů OJ PJ QJ o(H*OJ QJ 5B*OJ PJ QJ ph 5B*OJ PJ QJ o(ph 5OJ PJ QJ 5B*OJ PJ QJ o(ph 5B*OJ PJ QJ ph OJ QJ 5OJ 5B*OJ PJ o(ph 5B*OJ PJ ph :X Z \ ^ ` b d h j ` ^ p " . 6 < > @ H P ͿͿ仴 H*OJ PJ QJ o( H*OJ PJ QJ OJ PJ QJ o(OJ PJ QJ OJ o(5B*OJ PJ QJ o(ph 5B*OJ PJ QJ ph OJ QJ OJ QJ 5B*OJ PJ QJ ph 5B*OJ PJ QJ o(ph