演題概要

ポスター発表

第１日　６月１７日（水）　　P会場

1P-25　　PDF

Nano-PALDI MSイメージングを用いた経皮吸収による薬剤体内動態の可視化

(¹福井県大・ ²帝京大・ ³徳島大院ヘルスバイオ・ ⁴横国大)
^o山口菜月¹・ 菊池健太郎²・ 常山幸一³・ 森本翔大⁴・ 一柳優子⁴・ 植松宏平¹・ 片野肇¹・ 平修¹

We analyzed localization of methyl 2-octynate (2-OAm). 2-OAm (Mw: 154) is one of the xenobiotics that are used as additive substance of cosmetics. In this research, we investigated whether 2-OAm is delivered to the organ through percutaneous or not by nano-particle assisted laser desorption/ionization (Nano-PALDI) MS imaging. Nano-PALDI method enable to ionize and analyze small molecule without background compared with conventional method. 2-OAm was applied to once a day to mice body for 18 weeks. We revealed the localization of 2-OAm of liver under diverse conditions, visually. 2-OA accumulated at bile duct of liver with time.