3P-02 PDF
Solid-phase SALSAによる簡便な結合様式特異的シアル酸誘導体化
We have developed Sialic Acid Linkage-Specific Alkylamidation (SALSA) for linkage isomer discrimination. A drawback of SALSA is somewhat laborious purification steps to remove excess reagents for the reaction. In this study, SALSA was optimized for solid-phase reaction to facilitate purification steps. This solid-phase SALSA greatly minimized labor and time for derivatizing sialic acids in a linkage-specific manner. We believe that the solid-phase SALSA will be a good choice as a pretreatment of sialyl linkage analysis.