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Award Lectures
Day 1, June 22（Sun.） 13:50-14:10
Room A (Maesato West), Room B (Maesato Center), Room C (Top of Yaima)
- 1-AW-1350
Mass Spectrometry Studies on Higher-Order Structure of Biomacromolecules
(Yokohama City Univ.)
oSatoko Akashi
Native mass spectrometry (native MS), a technique that conducts analyses under conditions preserving the native state of molecules, is an effective method for discerning the roles of biological macromolecules, such as proteins and nucleic acids. This approach facilitates the ionization of assemblies formed by non-covalent interactions—including hydrogen bonding, electrostatic forces, and hydrophobic effects—within solutions mimicking physiological conditions. Consequently, native MS facilitates the accurate determination of assembly stoichiometry and provides crucial insights into biologically relevant interactions. The presentation will highlight our studies in applying mass spectrometry to: (1) higher-order structural analysis of proteins using top-down approaches; (2) quantitative analysis of molecular interaction strengths; (3) application of native mass spectrometry in structural biology; (4) native mass spectrometry for protein analysis under physiological conditions.