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Award Lectures
Day 1, June 22（Sun.） 14:30-14:50
Room A (Maesato West), Room B (Maesato Center), Room C (Top of Yaima)
- 1-AW-1430
Development of Thin metal Film formation Method For Surface-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging
(Toyama Pref. Univ.)
oIssey Osaka
Surface-assisted laser desorption/ionization (SALDI) mass spectrometry (MS) has been studied as a complementary analytical method to matrix-assisted laser desorption/ionization (MALDI)/MS. Graphite and metal nanoparticles have been reported as effective ionization facilitating materials for SALDI. I proposed SALDI/MS with metal thin films, in which a uniform metal thin film was deposited on the sample surface using sputtering. It enabled the highly sensitive detection of drugs, lipids and agricultural chemicals. Furthermore, I focused on mist chemical vapor deposition (mist CVD). Silver thin film was formed under atmospheric pressure with low heating load conditions by improving conventional mist CVD. Using these silver thin films for SALDI/MS imaging, I achieved an analysis of the distribution of lipids in brain tissue. I will highlight research on the metal film SALDI and its application.