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Poster Presentations
Day 1, June 22（Sun.）
Room P (Maesato East, Foyer, Ocean Wing)
- 1P-PM-07
Thin-section- and Matrix-free Mass Spectrometry Imaging: Platinum-coated Porous Plate Formed of Glass-beads (Transfer Plate) Realizes Various Sample Preparation
(1Hamamatsu Photonics, 2GPI)
oTakamasa Ikeda1,2
Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) is a powerful technique for visualizing the spatial distribution of chemical constituents of diverse samples, including biological tissues. Conventional MALDI-MSI procedures involve sample preparation steps, such as thin sectioning and matrix spraying. To streamline sample preparation for MSI, methods that eliminate the need for both thin sectioning and matrix spraying are highly desirable. One promising approach involves placing the measurement surface of the sample in direct contact with a prepared medium suitable for surface-assisted laser desorption/ionization (SALDI). Recently, a platinum-coated porous plate composed of glass beads (referred to as transfer plates) was identified as an effective SALDI medium, enabling thin-section- and matrix-free MSI via the transfer process. In this study, we performed three distinct transfer processes—contact, pressing, and crushing—utilizing transfer plates, and successfully obtained ion images. These results demonstrate the potential of transfer plates to simplify sample preparation for MSI, making them valuable tools for applications in biological and material sciences. Herein, we discuss the characteristics of each transfer process and the resulting MSI measurements.