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Oral Sessions
Day 2, June 23（Mon.） 14:10-14:25
Room A (Maesato West)
- 2A-O2-1410
Deciphering PM2.5-disrupted Energy Metabolism via Mass Spectrometry Analysis
(HKBU)
oZhu Yang
Fine particulate matter (PM2.5) is a major environmental health risk, contributing to millions of deaths annually. Its composition varies regionally, leading to diverse toxicological effects. Using mass spectrometry-based composition analysis, integrated with multi-omics approaches, we investigated PM2.5-induced disruptions in energy metabolism across multiple organs, focusing on Taiyuan, a heavily industrialized city in Northern China. Our findings reveal that PM2.5 exacerbates the cardiovascular risks of unhealthy diets and disrupts organ-specific metabolic pathways, including branched-chain amino acid metabolism in the spleen and lipoprotein metabolism in the liver. Year-round PM2.5 sampling from Taiyuan and Guangzhou (a Southern Chinese city) enabled mass spectrometry-based metabolomic profiling, uncovering region-specific metabolic shifts in lung cells. We identified phosphocholine as a key metabolite that counteracts PM2.5-induced energy imbalances by promoting fatty acid oxidation, restoring cellular energy homeostasis, and improving cell viability. These results highlight the utility of mass spectrometry and metabolomics in deciphering PM2.5's toxicological mechanisms and identifying potential therapeutic interventions. Our study provides critical insights into region-specific PM2.5 toxicity and offers a foundation for tailored public health strategies to mitigate its health impacts.