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Luncheon Seminar
Day 2, June 23（Mon.） 13:00-14:00
Room C (Top of Yaima)
- 2C-L-1300
Expanding the world of TIMS-enriched applications - Introduction of new Bruker MS technologies including the timsOmni MS platform
(1Bruker LLC, 2Bruker Singapore, 3Fasmatech)
oMike Greig1, Wen Donq Looi2, Dimitris Papanastasiou3, Athanasios Smyrnakis3, Mariangela Kosmopoulou3, Anastasios Grigoriadis3, Ioannis Orfanopoulos3, Nikolaos Manolis3, Ilias Panagiotopoulos3, Rafail Gioves3, Alexandros Lekkas3
The introduction of trapped ion mobility spectrometry (TIMS) has fundamentally changed the ways mass spectrometry labs approach proteomics, metabolomics, lipidomics and beyond. Bruker has continued to expand application space and build technologies to widen the range of molecules that can be analyzed as well as the depth of characterization capabilities. Innovative fragmentation schemes are an essential to enable detailed structural and/or sequence data necessary for precise molecular identifications. We report on the latest advances realized on the new timsOmni platform where novel offline as well as online data dependent acquisition (DDA) experimental workflows are applied for the analysis of multiple classes of analytes including proteins, antibodies, oligonucleotides, glycoproteins and small molecule pharmaceuticals.
Critical to the success of any application is the ability to rapidly and confidently analyze the often complex data. Top-down and middle-down data are processed in OmniScapeTM configured with an improved de novo sequencing algorithm for proteoform identification. A new DDA method supported by an ultra-fast charge state deconvolution algorithm for top down proteomics was evaluated.
The latest enhancements to our line of timsTOF mass spectrometers will also be discussed including the Athena Ion Processer and additional hardware updates.