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Oral Sessions
Day 2, June 23（Mon.） 15:40-15:55
Room C (Top of Yaima)
- 2C-O3-1540
Decoding functional signalling with personalized phosphoproteomics
(1Murdoch Children's Research Institute (MCRI), 2Charles Perkins Centre, University of Sydney, 3Cardiovascular Epidemiology Unit, University of Cambridge, 4Flinders Health and Medical Research Institute, 5Section of Molecular Physiology, University of Copenhagen)
oSean Humphrey1, Elise Needham3, Magnus Leandersson5, Hannah Huckstep1, Janni Petersen4, David James2, Jorgen Wojtaszewski5
Dysregulated cell signalling is a major driver of complex disease, and mass spectrometry has enabled the global and unbiased analysis of signalling (‘phosphoproteomics') for over a decade. Our high-throughput phosphoproteomics technology (‘EasyPhos') greatly improves the reproducibility, sensitivity, and feasibility of very large phosphoproteomics studies. High-throughput phosphoproteomics has accelerated the analysis of dynamic and in vivo signalling in diverse biological fields and organisms. In this talk I will discuss progress made in recent years, highlighting the application of this technology to large-scale studies of signalling in human skeletal muscle where the unbiased analysis of phosphorylation has demonstrated the power of this technology for uncovering signalling mechanisms driving fundamental biology. I will demonstrate through examples approaches we are developing to uncover and annotate functional signalling in a global and unbiased manner, and how these approaches are applicable to a broad range of cellular contexts and diseases.