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Poster Presentations
Day 2, June 23（Mon.）
Room P (Maesato East, Foyer, Ocean Wing)
- 2P-AM-23
Investigation of Mode of Action: Sorgolone Analogs Using Metabolomics
(1Kangwon Nat'l Univ., 2Konkuk Univ.)
oJung-Hoon Lee1, Eun-Song Choi1, Min-Ho Song1, Ha-Jin Son2, Ji-Yeon Lee2, Ji-Woo Yu1,2, Ji-Ho Lee1
Metabolomics is a scientific approach that analyzes metabolite fluctuations to elucidate metabolic changes. It can also be used to study the mode of action of new compounds. By identifying metabolic alterations, metabolomics enables the investigation of toxicity mechanisms. When combined with in vitro assays targeting known modes of action, it can serve as a powerful tool for elucidating the mechanisms of pesticides with unknown targets. In this study, metabolomics was applied to investigate the mode of action of herbicidal compounds.
Sorgoleone, a natural compound with allelopathic activity. To discover novel herbicides, structural analogs of sorgoleone were synthesized and tested against Lactuca sativa. Two analogs, 2-Hydroxy-5- methoxy-3-octadecyl-1,4-benzoquinone (1g) and 2-Hydroxy-5-methoxy-3-(2-Phenylethyl)-1,4- benzoquinone (1h), exhibited herbicidal effects. Previous studies suggest that sorgoleone exerts herbicidal effects through reactive oxygen species generation via photosystem II inhibition andinhibition of 4-hydroxyphenylpyruvate dioxygenase (HPPD). To assess metabolic changes associated with these mechanisms, GC-MS/MS-based metabolite profiling was conducted. Significant alterations were observed in ascorbate metabolism, glutathione metabolism, glyoxylate & dicarboxylate metabolism, vitamin B6 metabolism, and tyrosine metabolism. These findings provide insights into the potential mode of action of sorgoleone analogs with herbicidal activity.