The 10th Asia-Oceania Mass Spectrometry Conference (AOMSC2025) - organized by the Mass Spectrometry Society of Japan

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Day 2, June 23(Mon.) 

Room P (Maesato East, Foyer, Ocean Wing)

Biomonitoring of BPA and Parabens In The Urine of Children Aged 6 to 8 Years

(1IFSHRA, NYCU, 2IEOHS, NYCU)
oYu-Xing Cheng1, Mei-Lien Chen2, Yu-Fang Huang2

Bisphenol A (BPA) and parabens are endocrine-disrupting chemicals (EDCs) that can interfere with human hormones. They are commonly found in polycarbonate (PC) and are used as preservatives in food and cosmetics. In this study, BPA and four parabens, namely methyl-, ethyl-, propyl-, and butyl-parabens, were analyzed in urine samples using solid-phase extraction (SPE) and isotope-dilution ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). The limits of detection and limits of quantification ranged from 0.01 to 0.02 ng/mL and 0.02 to 0.06 ng/mL, respectively. The recovery rate and precision were between 80% and 100%, and ≦ 5%. The validated method was applied to 80 urine samples from children aged 6-8 years from the Taiwan Maternal Infant Cohort study (TMICs). This study will further analyze BPA and parabens exposure levels with demographics, lifestyle, diet, and potential sources of exposure to these chemicals and their health effects.