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Poster Presentations
Day 2, June 23（Mon.）
Room P (Maesato East, Foyer, Ocean Wing)
- 2P-AM-38
Maternal and Fetal Nicotine Metabolite Levels: An LC-MS/MS Study on ETS Exposure in the TBPS II Cohort
(1NTU EOHS, 2IPHS NHRI, 3NTCH, 4NTU PH, 5NTU MED, 6NIEHS NHRI)
oSih Yu Chen1, Mei Huei Chen2,3, Ching Chun Lin1, Pau Chung Chen1,4,5,6
Environmental tobacco smoke (ETS) comprises smoke from burning tobacco products and exhaled smoke, which poses significant risks to passive smokers, particularly pregnant women. ETS exposure is linked to adverse birth outcomes and long-term health complications for mothers and newborns. Assessing ETS exposure often involves maternal questionnaires or measure cotinine levels in maternal urine, blood, or umbilical cord blood. Beyond cotinine, ETS contains tobacco-specific nitrosamines (TSNAs), such as NNK, a Group 1 carcinogen according to the IARC. Its metabolite, NNAL, is considered to have a greater public health impact and predictive value for ETS-related health effects. However, information on cord blood NNK metabolite detection and maternal-fetal comparisons is still limited.
In our study, we used data from the Taiwan Birth Panel Study II (TBPS II), and we collected maternal blood samples pre-delivery and cord blood samples at delivery. We developed an LC-MS/MS method to quantify nicotine metabolites in cord blood, which demonstrates lower levels than in maternal blood. This research aims to provide a detailed evaluation of the health effects of ETS exposure during pregnancy, contributing valuable insights to public health.