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Poster Presentations
Day 2, June 23（Mon.）
Room P (Maesato East, Foyer, Ocean Wing)
- 2P-PM-09
Theoretical Study on Single-Stage Reflectron TOF MS Attaining an Ultra-High Resolution for High m/z Ions
(GRC)
oYi-Hong Cai, Yi-Sheng Wang
This study develops the fundamental principles of single-stage reflectron time-of-flight (R-TOF) mass spectrometry (MS) and demonstrates that second-order velocity focusing can be achieved when optimal experimental parameters are applied in MALDI ion sources. These parameters include total voltage, extraction voltage, and delayed extraction. The optimization model further reveals that delayed extraction is more effective than the reflector in compensating for the initial ion velocity spread, thereby improving mass resolving power (Rm). Calculations indicate that for ions with m/z 10,000, a single-stage R-TOF MS with a total instrument length of 1.2 meters (The effective total length: 2.4 meters) can achieve a Rm of 750,000. This discovery challenges traditional ion focusing theories and suggests that a single-stage reflectron TOF MS can overcome the limitation of ineffective ion focusing. Moreover, the calculation model also considers and predicts the optimal experimental parameters required for different ion masses. These findings are crucial for advancing R-TOF MS technology, providing a new theoretical framework to enhance mass resolution, ion focusing efficiency, and detection accuracy. The results of this study are particularly significant for biological, pharmaceutical, and analytical sciences, as ultra-high-resolution mass spectrometry is essential for precise molecular analysis.