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Poster Presentations
Day 2, June 23（Mon.）
Room P (Maesato East, Foyer, Ocean Wing)
- 2P-PM-26
Mass Analysis of Ultra-High Molecular Weight Polystyrene: a Comparison of Copper and Silver Salts Using MALDI LIT-MS
(1Department of Physics, National Dong Hwa Univ., 2Department of Chemistry, National Dong Hwa Univ.)
oThị Khánh Ly Lại1, Avinash Patil1, Ching-Chieh Lee1, Yi-Pang Chiu1, Zhe-Xuan Liu1, Che-Jen Lin2, Wen-Ping Peng1
This study presents the use of copper (Cu) and silver (Ag) salts in polymer mass spectrometry for the mass analysis of ultra-high molecular weight (UHMW) polystyrene (PS). Using matrix-assisted laser desorption/ionization (MALDI) coupled with a home-built linear ion trap mass spectrometer (LIT-MS), we achieved detection of PS with masses up to 2 MDa. Our method surpasses previous upper detection limits observed with Ag salt using a trans-2-[3-(4-tert-butylphenyl)-2-methyl-2-propenylidene]-malononitrile (DCTB) matrix.
The results demonstrate that both Ag and Cu salts can successfully analyze UHMW PS samples up to 2 MDa using the DCTB matrix. Ag salts generate multiply charged ion signals without control over their charge states. In contrast, copper(I) salts produce higher charge states up to +5, and copper(II) salts generate lower charge states up to +3. This superior versatility in modulating charge states simplifies mass analysis and enhances method flexibility, making Cu salts particularly valuable for analyzing both individual PS samples and mixtures.
Additionally, Cu salts are compatible with both DCTB and all-trans-retinoic acid (RA) matrices, with DCTB delivering superior performance. Comparative analysis with Ag salts further validates Cu salts for UHMW PS analysis, offering a powerful tool for mass distribution measurements and advancing analytical methods in polymer research.