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Luncheon Seminar
Day 3, June 24（Tue.） 12:45-13:45
Room B (Maesato Center)
- 3B-L-1245
Approach to cutting-edge research by MALDI-TOF MS
(Shimadzu Corp.)
oTakushi Yamamoto, Tsukasa Takeuchi, Ryo Yamaguchi
Using MALDI-TOFMS as a basic technology, Shimadzu has been developing various equipment, and is promoting cutting-edge research support, and the results will be reported in this seminar.
The progress of microbial analysis technology using MALDI-MS has been remarkable. We have applied MALDI-MS proteotyping, which assigns protein peaks observed by MALDI-MS based on genome information, to classify bacteria at the subspecies level, to the analysis of human skin flora. Although this method is highly reliable and has clear evidence supporting its analytical results, it requires specialized knowledge of bioinformatics. In collaboration with National Institute of Advanced Industrial Science and Technology we have developed a protein theoretical mass database of approximately 30,000 species (approximately 200,000 genomes) based on genome information of bacteria and archaea available in public databases, and a next-generation microbial analysis system equipped with a new identification algorithm using this database.
In addition, many applications of mass spectrometry imaging technology have been published. This technology is expected not only to improve the performance of mass spectrometers, but also to be used for pretreatment such as matrix spray method and simple data analysis after measurement. Shimadzu offers total solutions, and the latest application examples are reported.