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Luncheon Seminar
Day 4, June 25（Wed.） 12:45-13:45
Room A (Maesato West)
- 4A-L-1245
Unlocking Cellular Secrets: Cutting-Edge Single-Cell and Organelle Analysis for Drug Discovery
(1Yokogawa, 2Meijo Univ., 3KCL)
Yuta Terui1, oHajime Mizuno2, Melanie Bailey3, Masafumi Iharada1
Recent advancements in single-cell and organelle omics have improved our understanding of disease mechanisms and drug development. Yokogawa's Single CellomeTM System SS2000 enables the automated collection of single cells and organelles while observing live cells, facilitating intact metabolite analysis. Prof. Bailey will present a case study on ultra-low mass spectrometry using the SS2000 for viral and bacterial research, while Prof. Mizuno will discuss drug metabolism at the single-cell level using the SS2000 and Single CellomTM Unit SU10.
Biomarker detection, including metals, metabolites, lipids, and proteins, is crucial for studying diseases like cancer, diabetes, and infections. However, bulk tissue analysis may overlook critical cellular heterogeneity. Capillary sampling, a technique commercialized by Yokogawa, allows selective extraction of single cells or organelles under a confocal microscope. Advances in mass spectrometry using capillary-sampled materials provide new insights into how viruses and bacteria perturb cells and aid in optimizing cancer treatments.
This seminar will showcase innovative applications of SS2000 and SU10, demonstrating their role in enhancing analytical accuracy and efficiency in drug discovery and disease research.