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Oral Sessions
Day 4, June 25（Wed.） 14:40-14:55
Room C (Top of Yaima)
- 4C-O2-1440
Development of a Non-Invasive Early Detection Technique for Graves' Disease Using Thyroid Hormones in Hair
(1Kazusa DNA Res. Inst., 2Aderans, 3Ito hosp., 4Tohoku Univ.)
Kouhei Igarashi1,2, Chie Takita1,2, Masako Matsumoto3, Wataru Kitagawa3, Atsuko Ota2, Naoko Miyazaki3, Koichi Ito3, oKazutaka Ikeda1,4
Graves' disease (GD) is an autoimmune disorder that can be difficult to distinguish from other diseases due to symptom similarity. The exacerbation of GD owing to delayed diagnosis is a serious issue, and a novel accessible health screening system is needed. Therefore, this study investigated the association between GD and thyroid hormone levels in hair and evaluated the prediction accuracy of this non-invasive type of sample. By optimizing pretreatment and analysis techniques using liquid chromatography–mass spectrometry (LC-MS), free triiodothyronine (FT3) and thyroxine (FT4) could be detected in only 2 mg of hair with high sensitivity. Compared with healthy controls, the thyroid hormone levels in the hair of GD patients were significantly higher in correlation with blood levels. The predictive ability of hair thyroid hormones was analyzed using a receiver operating characteristic (ROC) curve, and the area under the curve (AUC) was 0.974 for FT3 and 0.900 for FT4, indicating a high level of determination accuracy. Our new approach offers the possibility to non-invasively and accurately detect GD using hair samples, and this system facilitates large-scale screening in locations such as hair salons and in-homes, potentially enabling the early detection of GD outside of medical facilities.