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Poster Presentations
Day 4, June 25（Wed.）
Room P (Maesato East, Foyer, Ocean Wing)
- 4P-AM-02（3B-O1-1140）
Single Tissue Multimodal Imaging for Cellular-level Spatial Metabolomics and Transcriptomics Analysis
(1HKBU, 2EIT Ningbo)
oThomas Ka Yam Lam1, Bingxu Zhang1, Jianing Wang1, Zongwei Cai1,2, Yiji Xia1
The advent of omics and spatial technologies has revolutionized modern research, enabling the simultaneous study of multiple molecular layers alongside tissue architecture and in-situ distribution. High-resolution spatial technologies reveal molecular crosstalk and interactions from the sub-regional to the sub-cellular level. This study presents the development of cellular-level multimodal imaging of transcriptomes and metabolomes by integrating novel spatial technologies, specifically Stereo-seq and matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI). We introduce a novel protocol that combines spatial transcriptomics and metabolomics, achieving 10μm spatial resolution and molecular depth. Our integrated spatial multiomics method offers the highest spatial resolution for cellular analysis to date. This method provides a comprehensive tool for exploring complex molecular and metabolic environments in cell-cell interactions within tissues, with significant implications for research and clinical applications.