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Poster Presentations
Day 4, June 25（Wed.）
Room P (Maesato East, Foyer, Ocean Wing)
- 4P-AM-15（3C-O1-1225）
Molecular composition and imaging profiles of thrombi in acute coronary syndrome
(Dokkyo Medical Univ.)
oMayo Wada, Tadayuki Ogawa, Setsu Nishino, Masashi Sakuma, Sigeru Toyoda
The molecular mechanisms of thrombus formation and pathogenesis still largely remain unclear. To address this issue, the molecular composition of acute coronary thrombi was analyzed by MSI and SEM-EDX. The molecular profile of lipids and elements in various types of thrombi will provide the basis for new risk management and treatment strategies for primary and secondary prevention. Acute coronary thrombi were obtained by thromboaspiration during PCI. Frozen sections of thrombi were analyzed by using MSI and SEM-EDX. The molecular data were further evaluated by the correlation with the patient background information. MSI analysis profiled the distribution and abundance of lipids in the thrombus.
In particular, cholesterol showed a significantly different distribution between plaque rupture, calcified nodule, and Lotus root. In addition, Principal Component Analysis also revealed the characteristic molecules and elements in the plaque rupture, plaque, lotus root, erosion, calcified nodule, and thromboembolism groups. The combination of MSI, elemental analysis and PCA effectively revealed the specific molecular distribution and composition of thrombi, which may provide the new insights for risk management and treatment strategies for primary and secondary prevention.