| Timetable |
| Download Conference Program |
| Download All Abstracts |
| Zoom Access |
| Corporate Program |
Poster Presentations
Day 4, June 25（Wed.）
Room P (Maesato East, Foyer, Ocean Wing)
- 4P-AM-52
The effect of orthokeratology lens wear on the proteins of tear fluid
(1Menicon, 2Nagoya Univ.)
oMadoka Yoshimitsu1, Yuri Shimizu1, Hikaru Hirata1, Keiko Kano2, Emi Mishiro-Sato2, Taizo Sumide1
Contact lenses are classified into two categories: conventional contact lenses including hydrogel contact lens (HyCL) and silicone hydrogel contact lens (SiHyCL) and specialty contact lenses including orthokeratology (OK) lens. OK is a method that uses specially designed contact lenses overnight to reshape the cornea to temporarily reduce or eliminate myopia. We have studied the effect of OK lens wear on the ocular surface. In this study, 9 subjects were classified into three groups: HyCL wearer group (n=3), SiHyCL wearer group (n=3) and no wearer group (n=3). All groups wore OK lenses for 2 months, and tear samples were collected at 0-day and after 2-months OK lens wearing. Proteins of these tear samples were compared under the following conditions: pre-OK lens wearing and post-OK lens wearing. Statistical analysis showed that the total number of proteins that changed significantly post-OK lens wearing compared to pre-OK lens wearing was 87 increased and 136 decreased in 9 subjects (p < 0.05). Enrichment analysis of these selected proteins showed that proteins involved in cell adhesion and cell proliferation were variable in all three groups, which was thought to be due to the reorganization of corneal epithelial cells caused by OK lens wear.