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Day 4, June 25（Wed.）
Room P (Maesato East, Foyer, Ocean Wing)
- 4P-CP-03
HIGH-THROUGHPUT PLASMA PROTEOMICS PIPELINE ENHANCED BIOMARKER DISCOVERY IN EARLY DETECTION OF NON-SMOKING LUNG CANCER
(1National Taiwan University, 2Academia Sinica Taipei, 3Academia Sinica, 4Thermo Fisher Scientific San Jose, 5Thermo Fisher Scientific Singapore, 6National Taiwan University Hospital, 7Chung Shan Medical University Hospital, 8National Taiwan University Hospital and National Taiwan University College of Medicine, 9National Taiwan University Hospital, Taipei, 10Thermo Fisher Scientific Poland)
Sung-Liang Yu1, Yi-Ju Chen2, Kun-Hao Chang2,3, Yi-Shuang Chuang2, Yi-Jing Hsiao2, Chong-Jen Yu6, Daniel Hermanson4, Gee-Chen Chang7, Jin-Shing Chen8, Pan-Chyr Yang9, Yu-Ju Chen2, Maciej Bromirski10, oNicole Zhang5
High cancer mortality rates highlight an urgent need for early detection. Plasma proteomics provides a minimally invasive approach for biomarker discovery for early-stage screening. However, the limited throughput of traditional mass spectrometry impedes large-scale discovery-validation studies. To overcome this bottleneck, we reported a high-throughput proteomics pipeline leveraging a modified Thermo Scientific™ Orbitrap™ Astral™ mass spectrometer (MS) with enhanced speed and sensitivity. This instrument offers high throughput of 60 samples per day, achieving deep coverage by identifying over 2,500 proteins in depleted-samples and nearly 5,000 in nanoparticle-enriched samples. The workflow is applied to the first LDCT screening trial (TALENT) for 12,000 never-smokers, providing a powerful platform for early biomarker discovery and a valuable data resource for lung diseases research.