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Poster Presentations
Day 4, June 25（Wed.）
Room P (Maesato East, Foyer, Ocean Wing)
- 4P-PM-05
A Comprehensive Strategy for Systematically Evaluating the Clinical Significance of Multiple Protein Biomarker Candidates in Bladder Cancer
(1Chang Gung University, 2Chang Gung Memorial Hospital)
oYi-Ting Chen1, Chien-Lun Chen2
This study reviewed and integrated relevant literature on bladder cancer biomarkers from 2012 to 2022. By incorporating our in-house research findings, we generated a list of potential bladder cancer biomarker candidates. A total of 122 protein biomarker candidates were identified and prioritized for verification based on their potential relevance to bladder cancer research. Our goal is to develop a multiplexed and targeted protein quantification method using LC-MRM-MS. We measured 90 protein biomarker candidates in urine samples from bladder cancer patients to assess the diagnostic potential of multiple protein biomarkers. Further analysis revealed that 29 molecules exhibited statistically significant differences between bladder cancer patients and controls. We will also report the preliminary results of the development of a rapid test kit based on the protein biomarker selected from mass spectrometry data. Additionally, a comparison of urinary protein levels between pre-operative and post-operative specimens showed a decrease in concentration in some cases at the first post-surgical time point, potentially due to the removal of tumor cells. This method enables the systematic measurement of changes in urinary protein concentrations before and after surgery, as well as during follow-up visits. Ultimately, the results will provide a valuable resource for both academic and clinical research.