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Poster Presentations
Day 4, June 25（Wed.）
Room P (Maesato East, Foyer, Ocean Wing)
- 4P-PM-10
MALDI Mass Spectrometry Using 2D Nanomaterial MXene for Rapid Screening of Illicit Drugs
(KRISS)
Jiyeong Song, Ji-In Baek, oSohee Yoon
The distribution and abuse of illicit drugs is a growing public problem worldwide, leading to a significant increase in the number of drug tests. The standard method for accurate drug analysis is chromatography-based mass spectrometry (MS), but this method has the limitation of long analysis time. To overcome these challenges, rapid screening techniques need to be developed and applied, and matrix-assisted laser desorption/ionization (MALDI) MS can be considered a suitable method for this purpose.
MXenes are emerging two-dimensional nanomaterials with excellent hydrophilicity, high ultraviolet‒visible (UV‒Vis) absorption, good charge mobility, and extensive application prospects for surface mass spectrometry. In this study, we developed a MALDI-MS method for rapid screening of illicit drugs using MXene. We selected Ti₂C₂ MXene to perform the analysis of four illicit drug compounds: methamphetamine, ketamine, ∆-THC, and fentanyl. We tested combinations of analytes and MXene under a variety of conditions and found that the combination of MXene and the organic matrix improved the analytical results for drugs compared to MXene alone. In addition, to simulate the testing of drug compounds in biological fluids, we mixed drug samples with biological fluids and performed rapid screening of illicit drugs using MALDI-MS. We will discuss the results in this presentation.