ポスター発表
- 第1日 5月15日（火） ポスター会場
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1P-11 PDF
LC-MS/MSによるマルチオミックス創薬
Osaka University Shimadzu Analytical Innovation R.L. is developing Garuda Software of Multi Omics (MO) for drug discovery by LC-MS/MS. The Nuclear Receptor (NR) binds both the promoter DNA and the hormone ligand as transcription factor (TF). The human 48 NR contain 40 orphan receptors and 8 endocrine receptors such as steroid hormones that are produced from cholesterol to glucocorticoide by metabolism with CYP11, 17, 19 and 21 etc. Some ligands of orphan NR are unknown. We believe MO to discover a new drug by LC-MS/MS. We identified many TF bound to a new promoter DNA of the platelet factor 4 (PF4) or a known promoter DNA of CYP3A4 by nanospray LC-MS/MS after in-gel tryptic digestion of spots SDS page electrophoresis.