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Poster Presentations
Day 3, June 12（Wed.） Room P1 (Multipurpose Hall)・Room P2 (Conference Room 101+102)
- 3P-21
Development of the High-Sensitivity and High-Resolution Post Processing Methods for Biopharmaceutical Analyses with Multi-Turn TOF-MS
(1Shimadzu, 2Osaka Univ.)
oHiroyuki Miura1, Yusuke Tateishi1, Hiroko Morinaga1, Koichi Kimura1, Masaru Nishiguchi1, Osamu Furuhashi1, Daisuke Okumura1, Yuki Yamaguchi2, Susumu Uchiyama2
In the field of quality control of biopharmaceuticals such as monoclonal antibodies (mAbs) and viral vectors, accurate and high-throughput analyses of chemical modification and protein degradation are important. We have been developing a high-resolution multi-turn TOF-MS system for analyses of biopharmaceuticals. In this study, we have developed new noise reduction and charge deconvolution methods for precise analysis with the multi-turn TOF-MS system.