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Poster Presentations
Day 3, June 12（Wed.） Room P1 (Multipurpose Hall)・Room P2 (Conference Room 101+102)
- 3P-41
MS Imaging Enabling Visualization of Lipid C=C Positional Isomers in Biological Tissues Using Oxygen Attachment Dissociation (OAD)
(Shimadzu)
oKaoru Nakagawa, Satoshi Kasamatsu, Kengo Takeshita, Manami Kobayashi, Hidenori Takahashi
Lipids are essential biomolecules that function as signaling molecules, energy sources, and skin barriers, in addition to constituting cell membranes. These diverse physiological functions are supported by the structural diversity of lipids. In particular, the position of the double bond (C=C) in the lipid structure is an important factor that determines the physical properties of biomembranes, substrate selectivity in metabolic reactions, and physiological functions of signaling molecules. Chemical derivatization, ozone-induced dissociation (OzID), ultraviolet photodissociation (UVPD), or electron-induced dissociation (EID), and ion mobility have been reported as separation techniques for lipid isomers in MS imaging (MSI). In this study, we implement Oxygen Attachment Dissociation (OAD)1-3), a fragmentation method that specifically dissociates C=C, in MSI to demonstrate the utility of this approach.