オーラルセッション
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1C-O3-1530（1P-36） PDF
チオール含有マトリックスを用いた抗腫瘍抗生物質のMALDI-MS分析
The enediyne natural products are effective drugs for cancer or leukemia owing to their strong DNA cleavage activity. Bioreduction triggers cyclization of their enediyne portion producing a 1,4-dehydrobenzene diradical species, and it abstracts two hydrogens from deoxyribose. MALDI mass spectrum of Esperamicin-A1, one of the first isolated enediyne antibiotics, with thiol containing matrix (2,5-Diamino-1,4-benzenedithiol) gave peaks of the cleavage of the trisulfide with thiols (m/z 1248) and cyclized analyte (m/z 1250, Esperamicin-Z). However, other matrixes including 1,4-Benzenedithiol gave no peaks of Esperamicin-Z.