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第1日　5月19日（水）　15:30～15:50　A会場（Zoom）

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糸状菌Trichoderma sp. RK10-F026より単離した培養条件依存的に生産される新規ペプタイボール類

(¹理研CSRS・ ²USM)
^o野川俊彦¹・ Rawa, Mira^1,2・ 岡野亜紀子¹・ 二村友史¹・ 中村健道¹・ Wahab, Habibah²・ 長田裕之¹

New 20-mer and 11-mer peptaibols were isolated from different culture conditions of a fungus, Trichoderma sp. RK10-F026, respectively, as culture condition depending metabolites by the screening of chemical properties using LC/MS and biological activities against cancer cell lines. Their structures were elucidated based on NMR, HR-MS, and MS/MS analysis. The absolute structures were confirmed by Marfey’s method. We report herein the isolation, structure, and biological activity of the new peptaibols.