Abstract

Poster Presentations

Day 3, May 21（Fri.）　　Room P1 (Zoom)

3P-05　　PDF

De novo Sequencing Analysis of a Linear Peptide in the Venom of the Scorpion Buthacus leptochelys

(¹Kyoto Univ., ²Al-Azhar Univ.)
^oMasato Tanaka¹, Yusuke Yoshimoto¹, Mohammed Abdel-wahab², Moustafa Sarhan², Masahiro Miyashita¹, Yoshiaki Nakagawa¹, Hisashi Miyagawa¹

Scorpions utilize venom to capture prey and protect themselves from predators by showing neurotoxicity against insects and mammals. The scorpion venom contains various components, in which peptides are main components responsible for the activities of the venom. Most of these peptides contain multiple disulfide bonds, but linear peptides without disulfide bonds are also present in the venom, which often exhibit antimicrobial activity. In this study, we searched for a linear peptide from the venom of the North African scorpion Buthacus leptochelys and determined its structure using de novo sequencing analysis.