Oral Sessions (Day1, Day2, Day3)
Poster Presentations
- Day 3, May 21（Fri.） Room P1 (Zoom)
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3P-11 PDF
The change of protein deposits on worn orthokeratology lenses treated with contact lens care regimens
Orthokeratology (OK) is a method that uses specially designed gas-permeable (GP) contact lenses overnight to reshape the cornea to temporarily reduce or eliminate myopia. The reverse-geometry back surface design of OK contact lenses provides an ideal place for deposits to adhere to the lens’ back surface, especially along the reverse zone, making these lenses more difficult to clean in comparison with traditional GP contact lenses. Previous studies have shown that surface deposits could potentially lead to a greater risk of lens-related microbial keratitis. In this study, the change of protein deposits on worn OK lenses treated with different contact lens care regimens was evaluated using the following methods: 1) Total volume of cloudiness over the lens surface in terms of volume per unit pixel (V/P) was assessed using image analysis software; 2) Quantitative value of protein deposits was assessed using nano-LC/MS/MS. These results show that the use of intensive cleaner was able to significantly reduce protein deposits to the level as unworn lens compared to daily cleaner. It is suggested that the importance of patients following an effective lens care regimen to remove deposits from the surfaces of their OK lenses.