The Mass Spectrometry society of Japan - The 68th Annual Conference on Mass Spectrometry, Japan

Abstract

Award Lecture

Day 2, June 23(Thu.) 18:10-18:30 Room A (Main Hall)

Development of radical-induced dissociation using atom/molecule-ion reaction and application to organic structural analysis

(Shimadzu)
oHidenori Takahashi

Radical-induced dissociation is initiated by the formation of radical intermediates on the target ion, in contrast to low-energy collision-induced dissociation of closed-shell ions such as protonated molecule [M + H]+. We have developed a novel radical-induced dissociation utilizing atom/molecule-ion reaction with atomic hydrogen and atomic oxygen/hydroxyl radicals as radical sources. Hydrogen and oxygen radical irradiation methods were useful for post-translational modification analysis and lipid analysis, respectively. In this lecture, we introduce the hardware development and application research related to our developed method.