Oral Sessions (Day1, Day2, Day3)
Poster Presentations (Day1, Day2, Day3)
Oral Sessions
- Day 2, June 23（Thu.） 10:20-10:40 Room A (Main Hall)
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2A-O1-1020 PDF
Generation of whole brain atlas for monoamines and anti-depressants localizations
Bioactive monoamines exert their effects by being transported to target regions in the brain that are remote from their producing cells. Therefore, it is difficult to understand in which neural nuclei monoamines are actually acting, only by studying the expression of monoamine-producing enzymes and transporters. In this study, a whole-brain distribution atlas of serotonin, dopamine, and norepinephrine was constructed for the first-time using imaging mass spectrometry (MS). As a result, several new neural nuclei with high serotonin accumulation were discovered.The paraventricular nucleus of the thalamus (PVT), a representative example, relays projections from the raphe nucleus, the center of serotonin synthesis, to various emotion regulation sites. These results suggest that the concept of "dynamic monoamine transport" from monoamine synthesis centers to specific neuronal nuclei including PVT may provide a new interpretation of the mechanisms of action of psychotropic drugs. In particular, how selective serotonin reuptake inhibitors (SSRIs) work outside the raphe-nucleus are largely unexplored, hampering our understanding of the complex drug effects of SSIRs. Here, we also evaluated the accumulation of SSRIs and changes in serotonin concentration in each neural nucleus in a whole-brain cross-sectional manner by simultaneously visualizing the kinetics of endogenous bioactive monoamines and exogenous administered drugs.