The Mass Spectrometry society of Japan - The 68th Annual Conference on Mass Spectrometry, Japan
Japanese

Abstract

Table of contents

Timetable

Plenary Lectures

Award Lecture

Oral Sessions (Day1, Day2, Day3)

Poster Presentations (Day1, Day2, Day3)

Panel Discussion

Luncheon Seminars (Day1, Day2, Day3)

Corporate Program

Oral Sessions

Day 2, June 23（Thu.）　10:00-10:20　Room B (409 and 410)

2B-O1-1000　　PDF

Development of Biomarker of Microglial Activation by Using Mass Spectrometry

(Shionogi)
oTatsuya Ikehara, Tatsuya Yanagawa, Sosuke Yoneda, Shigeki Omachi, Sayaka Fujita, Ryuta Tamano, Erika Kasai, Atsushi Obata

Microglial activation is known to cause diseases such as chronic pain. Currently, there is no biomarker of microglial activation that can be easily evaluated. We focused on 24S-hydroxycholesterol (24OHC) in blood as a novel biomarker of microglial activation. An analytical method of 24OHC by LC/MS/MS was developed and validated to investigate its potential as a biomarker of microglial activation in animal model or human.