The Mass Spectrometry society of Japan - The 68th Annual Conference on Mass Spectrometry, Japan
Japanese

Abstract

Table of contents

Timetable

Plenary Lectures

Award Lecture

Oral Sessions (Day1, Day2, Day3)

Poster Presentations (Day1, Day2, Day3)

Panel Discussion

Luncheon Seminars (Day1, Day2, Day3)

Corporate Program

Oral Sessions

Day 3, June 24（Fri.）　15:20-15:40　Room A (Main Hall)

3A-O2-1520　　PDF

Metabolic response analyses in tamoxifen-treated breast cancer cell line MCF-7 using time-series metabolomics

(1Osaka Univ., 2Osaka Univ., 3Osaka Univ., 4Shimadzu)
oNobuyuki Okahashi1,2, Kazuki Nishimoto1, Atsuhiko Toyama4, Junko Iida3,4, Fumio Matsuda1,2

In this study, time-series metabolomics was employed to analyze the metabolic responses in the 4-hydroxy tamoxifen (4-OHT)-treated human breast cancer cell line MCF-7. The results revealed that lipid biosynthesis from citrate was activated by 4-OHT treated apoptotic cells. Inhibition of the metabolic responses inhibited cell apoptosis, indicating that activation of lipogenesis via citrate decrease plays a role in inducing apoptosis.