Abstract

Oral Sessions

Day 3, June 24（Fri.）　16:20-16:40　Room A (Main Hall)

3A-O2-1620（3P-38）　　PDF

Lipidomic variations by the oxidative stress in the space flight

(¹Teikyo Univ., ²Tohoku Univ., ³Tohoku Univ., ⁴JAXA)
^oKaito Koike¹, Daisuke Saigusa^1,2, Akira Uruno^2,3, Takahumi Suzuki^2,3, Tomoko Fukuuchi¹, Noriko Yamaoka¹, Dai Shiba⁴, Masayuki Yamamoto^2,3

Space travel induces stresses that provoke health problems, and concomitantly induces the expression of Nrf2 (NF-E2-related factor-2) target genes that mediate adaptive responses to oxidative and other stresses1). While the variation of lipid species in white adipocytes (eWAT) have been identified2), detailed changes of lipid profiles, such as the level of fatty acid, remain unknown. Therefore, we have analyzed eWAT and liver tissues of flight mice and ground control including wild type and Nrf2 knockout mice by means of the lipidomic profiling using a UHPLC-FTMS. The level of eicosapentaenoic acid (EPA) type of phospholipids were significantly increased after space flight, suggesting that EPA may be the key factor for the novel function involved in antioxidant effects of Nrf2 in the space flight.