The Mass Spectrometry society of Japan - The 68th Annual Conference on Mass Spectrometry, Japan
Japanese

Abstract

Table of contents

Timetable

Plenary Lectures

Award Lecture

Oral Sessions (Day1, Day2, Day3)

Poster Presentations (Day1, Day2, Day3)

Panel Discussion

Luncheon Seminars (Day1, Day2, Day3)

Corporate Program

Oral Sessions

Day 3, June 24（Fri.）　15:20-15:40　Room D (413 and 414)

3D-O2-1520　　PDF

Detection of Breast Cancer-derived Substances by Using a Novel Transfer Plate for Mass Spectrometry Imaging

(1Kyushu Univ., 2Hamamatsu Photonics, 3Kyushu Univ., 4Imari Arita Hosp, 5GPI)
oKentaro Nonaka1, Takamasa Ikeda2, Takeshi Iwasaki1, Masataka Oeki3, Masahiro Kotani2, Takayuki Ohmura2, Hideto Sonoda1,4, Yasuhide Naito5, Mitsuru Tanaka3, Toshiro Matsui3, Eiji Oki1

Developing a new system to detect cancer-derived substances directly without any preparation is needed due to differences in human resources in each hospital. Breast cancer samples and 7 other frozen breast cancer tissues (T) and noncancerous tissues (N) were directly blotted to a novel transfer plate (Hamamatsu Photonics K.K.). We found several m/z peaks which showed significantly stronger intensity in T than N by the novel transfer plate aided-negative LDI-MS imaging. Furthermore, these m/z were showed reproducibly in all cancer tissue but limit detection in N. The combination m/z we found by using a novel transfer plate, may be useful for early detection and rapid diagnosis of breast cancer.