演題概要

オーラルセッション

第2日　6月23日（木）　10:00～10:20　B会場（409，410）

2B-O1-1000　　PDF

質量分析を活用した新規ミクログリア活性化マーカーの開発研究

(塩野義製薬)
^o池原達矢・ 柳川達也・ 米田聡介・ 大町成樹・ 藤田沙也香・ 玉野竜太・ 葛西えりか・ 小幡篤史

Microglial activation is known to cause diseases such as chronic pain. Currently, there is no biomarker of microglial activation that can be easily evaluated. We focused on 24S-hydroxycholesterol (24OHC) in blood as a novel biomarker of microglial activation. An analytical method of 24OHC by LC/MS/MS was developed and validated to investigate its potential as a biomarker of microglial activation in animal model or human.