演題概要

ポスター発表

第2日　6月23日（木）　　P会場（501，502，503）

2P-21　　PDF

高カロリー輸液に混合した塩酸メトクロプラミドの安定性評価

(¹神戸薬大・ ²姫獨大薬・ ³さくら薬局)
^o竹内敦子¹・ 都出千里¹・ 松川美佐子²・ 黒田英津子³・ 寺岡麗子²

Mass spectrometry is the effective analysis tool to get information on the structure and the concentration of the pharmaceuticals. It's also useful for the stability assessment of them. In this study, stability assessment of metoclopramide in injectable-mixed high-calorie infusion was performed by LTQ Orbitrap Discovery LC-MS/MS system. The remains rate of metoclopramide in high-calorie infusion including glucose fell remarkably under the acid condition. A new peak was appeared with a remains rate decline of metoclopramide. Analysis by LTQ Orbitrap Discovery LC-MS/MS system revealed that this peak was the condensation product of metoclopramide and glucose.