オーラルセッション
- 第3日 6月24日（金） 15:40～16:00 D会場（413，414）
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3D-O2-1540 PDF
生体分子の統合的オミクス解析：生体組織から分子、原子へ
In our body, various molecules constitute tissues and organs, and work efficiently to fulfill their physiological function by using their multidimensional features in a coordinated and dynamic manner. When the mechanism breaks down for some reason, its pathological modulation appears as disease. Therefore, it is important to obtain as much information as possible on the quality and localization of all molecules and atoms on the body tissue and to analyze them precisely in an integrated manner. In this talk, we will report on the integrated analyses of the same tissue from a living body by applying various analytical methods, combining the conventional histological analyses with MS Imaging, proteomics, LA(laser ablation)-ICP-MS, μPIXE (Particle Induced X-ray Emission). We will discuss the current situation and issues, and introduce our efforts on integrated omics analyses toward human disease samples in order to elucidate the disease mechanisms. Our studies show mass spectrometry is a promising approach that can deepen our knowledge on biological molecules in living tissue and molecular pathogenesis.