演題概要

ポスター発表

第3日　5月17日（水）　　P会場（ホワイエ，会議室1004-1007）

3P-23　　PDF

δサルコグリカン欠損による拡張型心筋症ハムスターの免疫代謝解析~マルチオミクス・イメージングを用いて

(¹同志社生命医・ ²島津・ ³摂南農・ ⁴京大院医・ ⁵国循研・ ⁶NCNP病院・ ⁷北摂総合病院)
^o岡邑舞子¹・ 山口真一²・ 山本卓志²・ 奥田晃士²・ 井上亮³・ 手嶋百合子⁴・ 袴田圭祐⁴・ 新谷祈¹・ 辻崇⁴・ 雨宮妃⁵・ 湊谷健司⁴・ 升本英利⁴・ 野口悟⁶・ 西野一三⁶・ 植田初江^5,7・ 池川雅哉¹

Dilated cardiomyopathies (DCM) is a group of progressive, poor prognosis diseases that primarily consist of ventricular enlargement and myocardial contractile dysfunction. J2N-k hamsters (J2N-k), which have a defective δ-sarcoglycan (δ-SG) encoding gene, have been utilized as a suitable DCM animal model because the dilation of the ventricles and dysfunction was noticeable at about 20 weeks of age. Currently, the precise phenotypes of J2N-k on heart and skeletal muscles have not been elucidated. In our previous study, we have detected several cardiovascular pathological features of J2N-k heart including inflammation, fibrosis, bone formation and giant cell in the early to mid-stage of J2N-k hamsters. In order to answer what is the molecular mechanism underlying cardiac pathology of J2N-k hamsters, here we adopt and integrate multi-modal imaging mass spectrometry in terms of immunometabolism in a spatially and temporally resolved manner.